Dev112375 1..7
نویسنده
چکیده
The requirement of leukemia inhibitory factor (LIF) for theestablishment and maintenance of mouse embryonic stem cells (ESCs) depends on thegenetic backgroundof theESCorigin. To reveal themolecular basis of the strain-dependent function of LIF, we compared the activation of the intracellular signaling pathways downstream of LIF in ESCs with different genetic backgrounds. We found that the JAK-Stat3 pathway was dominantly activated in ESCs derived from ‘permissive’ mouse strains (129Sv and C57BL6), whereas the MAP kinase pathway was hyperactivated in ESCs from ‘non-permissive’ strains (NOD, CBA and FVB). Artificial activation of Stat3 supported stable self-renewal of ESCs from non-permissive strains. These data suggest that the difference in the balance between the two intracellular signaling pathways underlies the differential response to LIF.
منابع مشابه
Dev112375 431..437
The requirement of leukemia inhibitory factor (LIF) for theestablishment and maintenance of mouse embryonic stem cells (ESCs) depends on thegenetic backgroundof theESCorigin. To reveal themolecular basis of the strain-dependent function of LIF, we compared the activation of the intracellular signaling pathways downstream of LIF in ESCs with different genetic backgrounds. We found that the JAK-S...
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position -4 C50 C49 C48 C47 C46 C45 C44 C43 C42 C41 C40 C39 C38 C37 C36 C35 C34 C33 C32 C31 C30 C29 C28 C27 C26 C25 C24 C23 C22 C21 C20 C19 C18 C17 C16 C15 C14 C13 C12 C11 C10 C9 C8 C7 C6 C5 C4 C3 C2 C1 C0 C-index SD P-value mark A 5 7 9 1 8 4 6 2 1 4 8 7 6 9 3 4 3 7 15 10 6 6 9 3 2 5 3 6 8 9 6 3 5 7 7 10 4 7 7 8 5 5 8 2 2 3 1 2 5 5 9 0.618 0.317 8.27E-03 n.s. A C 3 1 2 0 2 3 3 1 1 2 1 7 4 9 1 ...
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